Strange Carers

The present comment focuses on the distinction between attachment as bond formation and expectations of availability and responsiveness (security) within attachment relationships. We enumerate key components of bonding and functions of carer secure base support. Our analysis has implications for design and suggests that robots are unlikely to serve effectively as sole carers. Even with robots as part-time carers, attachment-like bonds would likely focus on human carers. Similarly, although infants and children would certainly build expectations regarding the availability and responsiveness of robot carers, the quality of human care would probably be the determining influence on later development and competence. Notwithstanding their limitations of robots as attachment figures they have considerable potential to extend parental care and enrich infant exploration. The Sharkey’s paper and further consideration of robots as carers for infants, children, older adults, an

Invariant manifolds and orbit control in the solar sail three-body problem

In this paper we consider issues regarding the control and orbit transfer of solar sails in the circular restricted Earth-Sun system. Fixed points for solar sails in this system have the linear dynamical properties of saddles crossed with centers; thus the fixed points are dynamically unstable and control is required. A natural mechanism of control presents itself: variations in the sail's orientation. We describe an optimal controller to control the sail onto fixed points and periodic orbits about fixed points. We find this controller to be very robust, and define sets of initial data using spherical coordinates to get a sense of the domain of controllability; we also perform a series of tests for control onto periodic orbits. We then present some mission strategies involving transfer form the Earth to fixed points and onto periodic orbits, and controlled heteroclinic transfers between fixed points on opposite sides of the Earth. Finally we present some novel methods to finding periodic orbits in circumstances where traditional methods break down, based on considerations of the Center Manifold theorem

Experimental versus theoretical log D_7.4, pK_a and plasma protein binding values for benzodiazepines appearing as new psychoactive substances

The misuse of benzodiazepines as new psychoactive substances is an increasing problem around the world. Basic physicochemical and pharmacokinetic data is required on these substances in order to interpret and predict their effects upon humans. Experimental log D7.4, pKa and plasma protein binding values were determined for 11 benzodiazepines that have recently appeared as new psychoactive substances (3‐hydroxyphenazepam, 4’‐chlorodiazepam, desalkylflurazepam, deschloroetizolam, diclazepam, etizolam, flubromazepam, flubromazolam, meclonazepam, phenazepam and pyrazolam) and compared with values generated by various software packages (ACD/I‐lab, MarvinSketch, ADMET Predictor and PreADMET). ACD/I‐LAB returned the most accurate values for log D7.4 and plasma protein binding while ADMET Predictor returned the most accurate values for pKa. Large variations in predictive errors were observed between compounds. Experimental values are currently preferable and desirable as they may aid with the future ‘training’ of predictive models for these new psychoactive substances

Research requirements to reduce maintenance costs of civil helicopters

The maintenance problems faced by the operators of civil helicopters that result in high costs are documented. Existing technology that can be applied to reduce maintenance costs and research that should be carried out were identified. Good design practice and application of existing technology were described as having a significant impact on reducing maintenance costs immediately. The research and development that have potential for long range reduction of maintenance costs are presented

Control of solar sail periodic orbits in the elliptic three-body problem

A solar sail essentially consists of a large mirror that uses the momentum change due to photons reflecting off the sail for its impulse. Solar sails are therefore unique spacecraft, as they do not require fuel for propulsion [1]. In this Note we consider using the solar sail to continuously maintain a periodic orbit above the ecliptic plane using variations in the sail's orientation. Positioning a spacecraft continuously above the ecliptic would allow continuous observation and communication with the poles

A two-fluid model for tissue growth within\ud a dynamic flow environment

We study the growth of a tissue construct in a perfusion bioreactor, focussing on its response to the mechanical environment. The bioreactor system is modelled as a two-dimensional channel containing a tissue construct through which a flow of culture medium is driven. We employ a multiphase formulation of the type presented by G. Lemon, J. King, H. Byrne, O. Jensen and K. Shakesheff in their study (Multiphase modelling of tissue growth using the theory of mixtures. J. Math. Biol. 52(2), 2006, 571–594) restricted to two interacting fluid phases, representing a cell population (and attendant extracellular matrix) and a culture medium, and employ the simplifying limit of large interphase viscous drag after S. Franks in her study (Mathematical Modelling of Tumour Growth and Stability. Ph.D. Thesis, University of Nottingham, UK, 2002) and S. Franks and J. King in their study (Interactions between a uniformly proliferating tumour and its surrounding: Uniform material properties. Math. Med. Biol. 20, 2003, 47–89).\ud \ud The novel aspects of this study are: (i) the investigation of the effect of an imposed flow on the growth of the tissue construct, and (ii) the inclusion of a mechanotransduction mechanism regulating the response of the cells to the local mechanical environment. Specifically, we consider the response of the cells to their local density and the culture medium pressure. As such, this study forms the first step towards a general multiphase formulation that incorporates the effect of mechanotransduction on the growth and morphology of a tissue construct. The model is analysed using analytic and numerical techniques, the results of which illustrate the potential use of the model to predict the dominant regulatory stimuli in a cell population